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In the brain, free radicals activate microglial cells, the resident immune cells of the central nervous system

Similarly, several studies suggest a protective effect of GPx1 against neurotoxicity in response to a variety of harmful substances, including 6-hydroxydopamine and malonate (reviewed in [116])

When macrophages and other immune cells engulf pathogens or damaged tissue debris, they generate large amounts of ROS, such as superoxide anions, hydrogen peroxide, via respiratory burst (148)

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